Key Characteristics
- Category: Injectable Peptides
- Purity: >99% Purity
- Molecular Formula: C111H186N36O27S2
- Molecular Weight: 2557.9 g/mol
- Sequence: CKGGRAKDC-GG-D(KLAKLAK)2
Available Sizes
About
Adipotide is an experimental peptidomimetic compound designed for targeted fat reduction by inducing apoptosis (programmed cell death) in the blood vessels supplying white adipose tissue.
Mechanism of Action
Adipotide consists of two domains: one that targets blood vessels supplying fat cells and another that triggers apoptosis. By binding to proteins prohibitin and ANXA2 on these vessels, it selectively disrupts their function, cutting off the nutrient supply to fat cells and causing them to shrink and die.
Key Benefits
- Targets white adipose tissue
- Induces apoptosis in fat cells
- Potential for significant weight loss
- May improve insulin resistance
Clinical Research
A landmark study in obese rhesus monkeys showed that daily Adipotide administration resulted in approximately 11% loss of body weight over 4 weeks, with significant reductions in abdominal circumference and BMI, alongside marked improvements in insulin resistance.
Potential Side Effects
The most significant side effect observed in primate studies was dose-dependent renal toxicity, specifically affecting the proximal tubules. This underscores its status as an experimental compound requiring careful research and monitoring.
Usage & Dosage
Research protocols often involve subcutaneous injections. Dosages in primate studies were cycled, for example, over 28-day periods followed by a washout period to mitigate potential side effects, particularly on the kidneys.
Peptide Storage
Best Practices For Storing Peptides
To preserve the integrity of laboratory results, proper storage of peptides is essential. Correct storage practices can maintain peptides for years and guard against contamination, oxidation, and degradation. If the peptides will be used immediately, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks.
For longer-term storage (several months to years), it is preferable to store peptides in a freezer at -80°C (-112°F). Avoid repeated freeze-thaw cycles and do not use frost-free freezers, as temperatures can fluctuate widely.
Preventing Contamination
To prevent moisture contamination, allow the peptide to come to room temperature before opening its container. Minimize exposure to air; after use, reseal the container under an atmosphere of dry, inert gas (like nitrogen or argon) if possible. Peptides with Cys, Met, or Trp are especially prone to air oxidation.
Storing Peptides In Solution
The shelf life of peptide solutions is far less than that of lyophilized peptides. If peptides must be stored in solution, use sterile buffers at pH 5-6 and separate into aliquots to avoid repeated freezing and thawing. Peptide solutions are generally stable for up to 30 days when refrigerated at 4°C (39°F).