Key Characteristics
- Category: GLPs
- Purity: >99% Purity
- Molecular Formula: C162H259N43O50
- Molecular Weight: 3650.1 g/mol
Available Sizes
About
Cagrilintide is a long-acting amylin analogue being researched for its potent effects on weight management, primarily through mechanisms that induce satiety and slow gastric emptying.
Mechanism of Action
Cagrilintide mimics the action of amylin, a hormone co-secreted with insulin. It binds to amylin receptors in the brain, enhancing the feeling of satiety, reducing food intake, and slowing the rate at which the stomach empties, providing a distinct approach to appetite control.
Key Benefits
- Promotes significant weight loss
- Slows gastric emptying to prolong satiety
- Acts on the brain to increase feelings of fullness
- Synergistic with GLP-1 agonists
Clinical Research
In a Phase 2 trial, once-weekly Cagrilintide injections demonstrated dose-dependent weight loss, with the highest dose leading to a 10.8% reduction in body weight over 26 weeks. When combined with Semaglutide (as 'CagriSema'), it showed even greater weight loss.
Potential Side Effects
Similar to other appetite-regulating hormones, the most common side effects are mild-to-moderate gastrointestinal events like nausea and decreased appetite.
Usage & Dosage
Administered via subcutaneous injection, typically once weekly in research settings. Dose escalation is often used to improve tolerability.
Peptide Storage
Best Practices For Storing Peptides
To preserve the integrity of laboratory results, proper storage of peptides is essential. Correct storage practices can maintain peptides for years and guard against contamination, oxidation, and degradation. If the peptides will be used immediately, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks.
For longer-term storage (several months to years), it is preferable to store peptides in a freezer at -80°C (-112°F). Avoid repeated freeze-thaw cycles and do not use frost-free freezers, as temperatures can fluctuate widely.
Preventing Contamination
To prevent moisture contamination, allow the peptide to come to room temperature before opening its container. Minimize exposure to air; after use, reseal the container under an atmosphere of dry, inert gas (like nitrogen or argon) if possible. Peptides with Cys, Met, or Trp are especially prone to air oxidation.
Storing Peptides In Solution
The shelf life of peptide solutions is far less than that of lyophilized peptides. If peptides must be stored in solution, use sterile buffers at pH 5-6 and separate into aliquots to avoid repeated freezing and thawing. Peptide solutions are generally stable for up to 30 days when refrigerated at 4°C (39°F).