Key Characteristics
- Category: Injectable Peptides
- Purity: >99% Purity
- Molecular Formula: C129H210N42O32
- Molecular Weight: 2909.4 g/mol
- Sequence: Ac-L-T-L-R-K-E-P-A-S-E-I-A-Q-S-I-L-E-A-Y-Q-N-G-P-S-S-NH2
Available Sizes
About
FOXO4-DRI is a senolytic peptide designed to selectively induce apoptosis (cell death) in senescent (aging) cells, potentially reversing some age-related tissue dysfunction.
Mechanism of Action
FOXO4-DRI works by blocking the interaction between FOXO4 and p53, an interaction that prevents senescent cells from undergoing apoptosis. By disrupting this link, the peptide allows the natural process of cell death to proceed, clearing out dysfunctional aging cells.
Key Benefits
- Selectively eliminates senescent cells
- May restore tissue homeostasis and function
- Potential to reverse age-related markers
- Studied for benefits in hair growth, kidney function, and vitality
Clinical Research
In a landmark study on rapidly aging mice, administration of FOXO4-DRI restored hair growth, improved kidney function, and increased physical activity, demonstrating its powerful senolytic effects.
Potential Side Effects
FOXO4-DRI is a potent and relatively new research compound. The main concern is ensuring it only targets senescent cells. Long-term side effects in humans are unknown.
Usage & Dosage
Administered via subcutaneous injection. In mouse studies, it was used intermittently (e.g., 3 times a week for 4 weeks). Human equivalent dosages and optimal protocols are still under investigation.
Peptide Storage
Best Practices For Storing Peptides
To preserve the integrity of laboratory results, proper storage of peptides is essential. Correct storage practices can maintain peptides for years and guard against contamination, oxidation, and degradation. If the peptides will be used immediately, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks.
For longer-term storage (several months to years), it is preferable to store peptides in a freezer at -80°C (-112°F). Avoid repeated freeze-thaw cycles and do not use frost-free freezers, as temperatures can fluctuate widely.
Preventing Contamination
To prevent moisture contamination, allow the peptide to come to room temperature before opening its container. Minimize exposure to air; after use, reseal the container under an atmosphere of dry, inert gas (like nitrogen or argon) if possible. Peptides with Cys, Met, or Trp are especially prone to air oxidation.
Storing Peptides In Solution
The shelf life of peptide solutions is far less than that of lyophilized peptides. If peptides must be stored in solution, use sterile buffers at pH 5-6 and separate into aliquots to avoid repeated freezing and thawing. Peptide solutions are generally stable for up to 30 days when refrigerated at 4°C (39°F).