Key Characteristics
- Category: Injectable Peptides
- Purity: >99% Purity
- Molecular Formula: C55H75N17O13
- Molecular Weight: 1182.3 g/mol
- Sequence: pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
Available Sizes
About
Gonadorelin is a synthetic version of GnRH, the master hormone that stimulates the pituitary to release Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), which are essential for testosterone and estrogen production.
Mechanism of Action
Gonadorelin binds to GnRH receptors on the pituitary gland, causing a pulsatile release of LH and FSH. This action stimulates the gonads (testes or ovaries) to produce sex hormones. Its short half-life makes it ideal for mimicking natural hormonal pulses.
Key Benefits
- Stimulates the release of LH and FSH
- Can be used to assess pituitary function
- Used in protocols to restart the HPTA axis
- Mimics natural pulsatile hormone release
Clinical Research
Gonadorelin is an FDA-approved drug used in medicine to treat delayed puberty, infertility, and for diagnostic purposes to test hypothalamic-pituitary function. It is a well-understood and foundational hormone peptide.
Potential Side Effects
When used in a pulsatile manner, side effects are rare. Continuous administration, however, can lead to downregulation of the HPTA and a shutdown of sex hormone production.
Usage & Dosage
For HPTA restart protocols, it is administered subcutaneously in small, frequent pulses (e.g., 50-100mcg several times a day) to mimic the body's natural rhythm.
Peptide Storage
Best Practices For Storing Peptides
To preserve the integrity of laboratory results, proper storage of peptides is essential. Correct storage practices can maintain peptides for years and guard against contamination, oxidation, and degradation. If the peptides will be used immediately, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks.
For longer-term storage (several months to years), it is preferable to store peptides in a freezer at -80°C (-112°F). Avoid repeated freeze-thaw cycles and do not use frost-free freezers, as temperatures can fluctuate widely.
Preventing Contamination
To prevent moisture contamination, allow the peptide to come to room temperature before opening its container. Minimize exposure to air; after use, reseal the container under an atmosphere of dry, inert gas (like nitrogen or argon) if possible. Peptides with Cys, Met, or Trp are especially prone to air oxidation.
Storing Peptides In Solution
The shelf life of peptide solutions is far less than that of lyophilized peptides. If peptides must be stored in solution, use sterile buffers at pH 5-6 and separate into aliquots to avoid repeated freezing and thawing. Peptide solutions are generally stable for up to 30 days when refrigerated at 4°C (39°F).