Key Characteristics
- Category: Injectable Peptides
- Purity: >99% Purity
- Molecular Formula: C50H69N15O9
- Molecular Weight: 1024.2 g/mol
- Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Available Sizes
About
Melanotan-II is a synthetic analogue of α-Melanocyte-Stimulating Hormone (α-MSH) researched for its ability to induce skin pigmentation (tanning) and its effects on libido.
Mechanism of Action
MT-II is a non-selective agonist of the melanocortin receptors. Its binding to the MC1R stimulates melanin production in melanocytes, leading to skin darkening. Its binding to other receptors, particularly MC3R and MC4R in the brain, is thought to be responsible for its effects on appetite suppression and increased sexual arousal.
Key Benefits
- Induces skin pigmentation (tanning)
- May increase libido and sexual function
- Can act as an appetite suppressant
- Potential neuroprotective and anti-inflammatory effects
Clinical Research
Human studies have confirmed MT-II's ability to cause significant skin tanning with minimal UV exposure. Its effects on sexual arousal led to the development of PT-141 (Bremelanotide), a more specific derivative.
Potential Side Effects
Common side effects include facial flushing, nausea, and spontaneous erections shortly after administration. Increased darkening of moles and freckles is also expected.
Usage & Dosage
Administered via subcutaneous injection. Research protocols often start with very low doses (e.g., 100mcg) to assess tolerance, gradually increasing as needed.
Peptide Storage
Best Practices For Storing Peptides
To preserve the integrity of laboratory results, proper storage of peptides is essential. Correct storage practices can maintain peptides for years and guard against contamination, oxidation, and degradation. If the peptides will be used immediately, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks.
For longer-term storage (several months to years), it is preferable to store peptides in a freezer at -80°C (-112°F). Avoid repeated freeze-thaw cycles and do not use frost-free freezers, as temperatures can fluctuate widely.
Preventing Contamination
To prevent moisture contamination, allow the peptide to come to room temperature before opening its container. Minimize exposure to air; after use, reseal the container under an atmosphere of dry, inert gas (like nitrogen or argon) if possible. Peptides with Cys, Met, or Trp are especially prone to air oxidation.
Storing Peptides In Solution
The shelf life of peptide solutions is far less than that of lyophilized peptides. If peptides must be stored in solution, use sterile buffers at pH 5-6 and separate into aliquots to avoid repeated freezing and thawing. Peptide solutions are generally stable for up to 30 days when refrigerated at 4°C (39°F).