Key Characteristics
- Category: GLPs
- Purity: >99% Purity
- Molecular Formula: C221H343N47O67
- Molecular Weight: 4731.3 g/mol
Available Sizes
About
Retatrutide is a novel, investigational triple-agonist peptide that activates the GLP-1, GIP, and glucagon receptors, making it one of the most powerful metabolic compounds in research.
Mechanism of Action
Retatrutide combines GLP-1 and GIP agonism for appetite suppression and glycemic control with glucagon receptor agonism. The glucagon action is unique, as it increases energy expenditure and promotes the breakdown of fats (lipolysis). This tri-agonist action attacks metabolic dysfunction from three angles: reducing intake, improving glucose disposal, and increasing energy output.
Key Benefits
- Unprecedented weight loss results in clinical trials
- Triple-receptor action for comprehensive metabolic control
- Increases energy expenditure
- Improves insulin sensitivity and reduces liver fat
Clinical Research
A landmark Phase 2 trial showed that participants on the highest dose of Retatrutide lost an average of 24.2% of their body weight over 48 weeks, the highest level of weight loss ever recorded for a pharmaceutical in a Phase 2 study.
Potential Side Effects
The side effect profile is consistent with the incretin class, consisting mainly of dose-related, transient gastrointestinal events like nausea and diarrhea.
Usage & Dosage
Administered once weekly via subcutaneous injection. Research protocols involve a dose titration schedule to reach a maintenance dose.
Peptide Storage
Best Practices For Storing Peptides
To preserve the integrity of laboratory results, proper storage of peptides is essential. Correct storage practices can maintain peptides for years and guard against contamination, oxidation, and degradation. If the peptides will be used immediately, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks.
For longer-term storage (several months to years), it is preferable to store peptides in a freezer at -80°C (-112°F). Avoid repeated freeze-thaw cycles and do not use frost-free freezers, as temperatures can fluctuate widely.
Preventing Contamination
To prevent moisture contamination, allow the peptide to come to room temperature before opening its container. Minimize exposure to air; after use, reseal the container under an atmosphere of dry, inert gas (like nitrogen or argon) if possible. Peptides with Cys, Met, or Trp are especially prone to air oxidation.
Storing Peptides In Solution
The shelf life of peptide solutions is far less than that of lyophilized peptides. If peptides must be stored in solution, use sterile buffers at pH 5-6 and separate into aliquots to avoid repeated freezing and thawing. Peptide solutions are generally stable for up to 30 days when refrigerated at 4°C (39°F).