Key Characteristics
- Category: GLPs
- Purity: >99% Purity
- Molecular Formula: C187H291N45O59
- Molecular Weight: 4113.6 g/mol
Available Sizes
About
Semaglutide is a highly effective GLP-1 (glucagon-like peptide-1) receptor agonist, renowned for its significant impact on weight management and glycemic control.
Mechanism of Action
Semaglutide mimics the native incretin hormone GLP-1. It activates GLP-1 receptors in the brain to suppress appetite, slows gastric emptying to increase satiety, and stimulates glucose-dependent insulin secretion from the pancreas.
Key Benefits
- Powerful appetite suppression
- Clinically proven, significant weight loss
- Improves glycemic control
- Reduces risk of major cardiovascular events
Clinical Research
The STEP clinical trial program demonstrated that once-weekly Semaglutide resulted in average weight loss of ~15-17% from baseline in individuals with obesity, a landmark result for anti-obesity medications.
Potential Side Effects
The most common side effects are gastrointestinal and dose-dependent, including nausea, diarrhea, vomiting, and constipation, which typically lessen over time.
Usage & Dosage
Administered via subcutaneous injection, typically once weekly. Research protocols involve a dose-escalation schedule to improve tolerability, often starting at 0.25mg and titrating up to a maintenance dose of 1.7mg or 2.4mg.
Peptide Storage
Best Practices For Storing Peptides
To preserve the integrity of laboratory results, proper storage of peptides is essential. Correct storage practices can maintain peptides for years and guard against contamination, oxidation, and degradation. If the peptides will be used immediately, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks.
For longer-term storage (several months to years), it is preferable to store peptides in a freezer at -80°C (-112°F). Avoid repeated freeze-thaw cycles and do not use frost-free freezers, as temperatures can fluctuate widely.
Preventing Contamination
To prevent moisture contamination, allow the peptide to come to room temperature before opening its container. Minimize exposure to air; after use, reseal the container under an atmosphere of dry, inert gas (like nitrogen or argon) if possible. Peptides with Cys, Met, or Trp are especially prone to air oxidation.
Storing Peptides In Solution
The shelf life of peptide solutions is far less than that of lyophilized peptides. If peptides must be stored in solution, use sterile buffers at pH 5-6 and separate into aliquots to avoid repeated freezing and thawing. Peptide solutions are generally stable for up to 30 days when refrigerated at 4°C (39°F).