Key Characteristics
- Category: Injectable Peptides
- Purity: >99% Purity
- Molecular Formula: C32H49N9O5
- Molecular Weight: 639.8 g/mol
- Sequence: D-Arg-Dmt-Lys-Phe-NH2
Available Sizes
About
SS-31 is a mitochondria-targeting peptide that enhances mitochondrial function and reduces oxidative stress, with research focused on age-related diseases, cardiovascular health, and neuroprotection.
Mechanism of Action
SS-31 selectively targets and concentrates in the inner mitochondrial membrane. It interacts with cardiolipin, a key lipid, to improve the structure and function of the electron transport chain, leading to more efficient ATP production and reduced formation of reactive oxygen species (ROS).
Key Benefits
- Enhances mitochondrial function and ATP production
- Reduces oxidative stress
- Potential benefits for cardiovascular, renal, and neurodegenerative diseases
- Improves cellular bioenergetics
Clinical Research
Elamipretide (SS-31) has been studied in numerous clinical trials for conditions like heart failure, mitochondrial myopathy, and ophthalmic diseases. It has shown promise in improving mitochondrial function and reducing symptoms in these age-related conditions.
Potential Side Effects
SS-31 has demonstrated a good safety profile in clinical trials, with the most common side effect being mild to moderate injection site reactions.
Usage & Dosage
Administered via subcutaneous injection. Dosages in human clinical trials have varied, but are often in the range of 15-40mg per day.
Peptide Storage
Best Practices For Storing Peptides
To preserve the integrity of laboratory results, proper storage of peptides is essential. Correct storage practices can maintain peptides for years and guard against contamination, oxidation, and degradation. If the peptides will be used immediately, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks.
For longer-term storage (several months to years), it is preferable to store peptides in a freezer at -80°C (-112°F). Avoid repeated freeze-thaw cycles and do not use frost-free freezers, as temperatures can fluctuate widely.
Preventing Contamination
To prevent moisture contamination, allow the peptide to come to room temperature before opening its container. Minimize exposure to air; after use, reseal the container under an atmosphere of dry, inert gas (like nitrogen or argon) if possible. Peptides with Cys, Met, or Trp are especially prone to air oxidation.
Storing Peptides In Solution
The shelf life of peptide solutions is far less than that of lyophilized peptides. If peptides must be stored in solution, use sterile buffers at pH 5-6 and separate into aliquots to avoid repeated freezing and thawing. Peptide solutions are generally stable for up to 30 days when refrigerated at 4°C (39°F).