Key Characteristics
- Category: GLPs
- Purity: >99% Purity
- Molecular Formula: C225H348N48O68
- Molecular Weight: 4813.5 g/mol
Available Sizes
About
Tirzepatide is a first-in-class dual-agonist peptide that activates both the GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, providing powerful, synergistic effects on metabolic health.
Mechanism of Action
Tirzepatide's dual agonism enhances the effects of GLP-1 receptor activation. The GIP action complements GLP-1 by further improving insulin secretion and potentially contributing to appetite regulation and fat metabolism. This 'twincretin' effect results in more profound improvements in glucose control and body weight.
Key Benefits
- Superior weight loss compared to single-agonists
- Powerful dual-action on GLP-1 and GIP receptors
- Enhanced glycemic control
- Broad improvements in cardiometabolic markers (lipids, blood pressure)
Clinical Research
The SURMOUNT trial program showed unprecedented weight loss, with participants on the highest dose losing up to 22.5% of their body weight. The SURPASS trials demonstrated its superiority in glucose lowering compared to other diabetes medications.
Potential Side Effects
Similar to other incretin-based therapies, side effects are primarily gastrointestinal (nausea, diarrhea, etc.), dose-dependent, and tend to decrease over time.
Usage & Dosage
Administered via subcutaneous injection once weekly. Research protocols use a dose-escalation schedule, starting at 2.5mg and increasing every 4 weeks to maintenance doses of 5mg, 10mg, or 15mg.
Peptide Storage
Best Practices For Storing Peptides
To preserve the integrity of laboratory results, proper storage of peptides is essential. Correct storage practices can maintain peptides for years and guard against contamination, oxidation, and degradation. If the peptides will be used immediately, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks.
For longer-term storage (several months to years), it is preferable to store peptides in a freezer at -80°C (-112°F). Avoid repeated freeze-thaw cycles and do not use frost-free freezers, as temperatures can fluctuate widely.
Preventing Contamination
To prevent moisture contamination, allow the peptide to come to room temperature before opening its container. Minimize exposure to air; after use, reseal the container under an atmosphere of dry, inert gas (like nitrogen or argon) if possible. Peptides with Cys, Met, or Trp are especially prone to air oxidation.
Storing Peptides In Solution
The shelf life of peptide solutions is far less than that of lyophilized peptides. If peptides must be stored in solution, use sterile buffers at pH 5-6 and separate into aliquots to avoid repeated freezing and thawing. Peptide solutions are generally stable for up to 30 days when refrigerated at 4°C (39°F).